Improving polygenic prediction in ancestrally diverse populations

Polygenic risk scores (PRS) have attenuated cross-population predictive performance, which reduces their clinical value in non-European populations and exacerbates healthcare disparities. This study, conducted by CGM Investigators Tian Ge, Hailiang Huang, Alicia Martin and colleagues, developed a computational framework, termed PRS-CSx, that can integrate genomic data from multiple populations to improve polygenic prediction in diverse populations. Leveraging large-scale global biobanks and disease-focused cohorts, the investigators showed that PRS-CSx substantially improved the prediction accuracy of biomarkers and disease risk in non-European populations. This work represents an important step towards the implementation of PRS into routine healthcare.

Read more in Nature Genetics

December 13, 2022

Publication Name

CGM Primary Investigators