Oxygen restriction’s effects on lifespan

Oxygen restriction has been linked to longer lifespan in some organisms, but its effects on aging in mammals have been unclear. A team led by CGM faculty member, Vamsi Mootha, and Robert Rogers explored the effects of oxygen restriction on mammalian lifespan using a mouse model of accelerated aging. The researchers discovered that the mice living in an oxygen-restricted environment lived about 50 percent longer compared to those exposed to standard levels of oxygen, with delayed onset of aging-associated neurological deficits.

Read more in news releases from PLOS and Harvard Medical School, and coverage in The Daily Beast and Medical News Today.

March 21, 2023


CGM Primary Investigator