Nucleosides Associated With Incident Ischemic Stroke in the REGARDS and JHS Cohorts
This manuscript is the first to show a link between specific nucleoside metabolites and the risk of future stroke, independent of traditional stroke risk factors. In this study, CGM Investigator Taylor Kimberly and colleagues also sought to determine whether these candidates were a reflection of genes or environment through GWA studies. Their findings suggest that the top metabolites were related to environmental or behavioral patterns, ultimately leading our group to focus on potential links between diet, the gut microbiome, and stroke risk.
Read more in Neurology.
The Center for Genomic Medicine (CGM) comprises one of the largest and most vibrant hubs of genomic medicine research in the world. The CGM includes 46 faculty collaborating to define the ‘genomic medicine cycle’ – which envisages a genomics community seeking to advance research from basic genomics research to ultimately using genome information for diagnostics and targeted therapeutics. All of our investigators are faculty at Harvard Medical School, and many members of our community are also investigators at the Broad Institute of Harvard and MIT.
