Riboflavin depletion promotes longevity and metabolic hormesis in Caenorhabditis elegans

This study makes a very important statement about assumptions that have been made regarding what is “good for you” in aging. In this study led by CGM Investigator Alex Soukas and CGM and MGH Endocrine Instructor Armen Yerevanian, the authors show that reducing levels of an essential vitamin, riboflavin, which is necessary to make the cofactor FAD, is beneficial in aging, prompting stress defenses and promoting lifespan extension in C. elegans. While there is a ways to go to prove benefits in humans, it challenges the “dogma” that with vitamins more is better for you.

December 6, 2022


CGM Primary Investigator