Detecting obstructive sleep apnea (OSA) is important to both prevent significant comorbidities in people with Down syndrome (DS) and untangle contributions to other behavioral and mental health diagnoses. However, laboratory-based polysomnograms are often poorly tolerated, unavailable, or not covered by health insurance for this population. This work published by CGM investigator Brian Skotko and colleagues leveraged a previously developed prediction model that held promise in identifying which people with DS might not have significant apnea. In a novel set of participants with DS, a clinically reliable screening tool for OSA in people with DS that bypasses the need for laboratory-based polysomnography (sleep studies) was not achieved. This work, importantly, indicates that patients with DS should continue to be monitored for OSA according to current healthcare guidelines.