Focus Areas in the Genomic Medicine Cycle
Major leadership positions

Investigator, Howard Hughes Medical Institute

Institute Member, Broad Institute

MGH Department/Division

Molecular Biology

MGH Unit(s)

Mitochondrial Medicine Unit


The long-term goals of the Mootha Laboratory are to combine the new tools of genomics and systems biology with classic biochemistry to investigate mitochondrial bioenergetics, evolution, and disease.

Priority Projects

  1. Diversity of the mitochondrial proteome across organs and organisms.
  2. Investigating mtDNA variation: from single-cells to biobank-scale
  3. Harnessing hypoxia as a novel therapeutic approach to mitochondrial disease
  4. Developing new genetic tools for investigating energy metabolism

Lab Members

Fanny NgMGH Lab Manager
Naomi OstrikerBroad Lab Manager
Bryanna VacantiGrant Administrator
Lab/Contact Telephone


Primary Email

vamsi [@]

Lab Website