This manuscript builds on the Kimberly Lab’s work that highlights the role of the interleukin-33/ST2 pathway and its link to post-stroke inflammation and brain edema. The lab had previously shown that this inflammatory signaling cascade is associated with brain edema and activation of innate immunity after ischemic stroke and subarachnoid hemorrhage. This paper extends previous work to show a similarly damaging activation after intracerebral hemorrhage. Collectively, this work highlights that modulation of the IL-33/ST2 pathway is a candidate target to reduce the severity of edema and inflammation after all major forms of acute brain injury.