Oxygen restriction’s effects on lifespan
Oxygen restriction has been linked to longer lifespan in some organisms, but its effects on aging in mammals have been unclear. A team led by CGM faculty member, Vamsi Mootha, and Robert Rogers explored the effects of oxygen restriction on mammalian lifespan using a mouse model of accelerated aging. The researchers discovered that the mice living in an oxygen-restricted environment lived about 50 percent longer compared to those exposed to standard levels of oxygen, with delayed onset of aging-associated neurological deficits.
Read more in news releases from PLOS and Harvard Medical School, and coverage in The Daily Beast and Medical News Today.
The Center for Genomic Medicine (CGM) comprises one of the largest and most vibrant hubs of genomic medicine research in the world. The CGM includes 46 faculty collaborating to define the ‘genomic medicine cycle’ – which envisages a genomics community seeking to advance research from basic genomics research to ultimately using genome information for diagnostics and targeted therapeutics. All of our investigators are faculty at Harvard Medical School, and many members of our community are also investigators at the Broad Institute of Harvard and MIT.
