Whole genome sequence analysis of blood lipid levels in >66,000 individuals

Calcific aortic stenosis is one of the most common valvular heart diseases and has no efficacious medical therapy. In a multi-ancestry genome wide association study of 14,451 individuals with calcific aortic stenosis in the Million Veteran Program, Small et al discovered 6 novel genomic regions in the disease. Novel findings included variants near CEP85L, FTO, SLMAP, CELSR2, MECOM, and CDAN1 – together implicating complex pathobiology with contributions by lipid metabolism, inflammation, cellular senescence, and adiposity.

Read more in Nature Communications

June 21, 2023


CGM Primary Investigator